Dr. Karan Goswami Wins EOA Parvizi Musculoskeletal Infection Award

For “Fracture-linked Microbiome and Persistent Nonunion: Future-Technology Sequencing Reveals” Investigate Paper

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Oct 8, 2021 16:00 EDT


Dr. Karan Goswami of the Rothman Orthopaedic Institute at Thomas Jefferson University has been given the prestigious Eastern Orthopaedic Association’s Parvizi Musculoskeletal An infection Award for his paper entitled “Fracture-linked Microbiome and Persistent Nonunion: Up coming-Era Sequencing Reveals.” This award is supplied to a Resident or Fellow with a person of the prime papers offered at the EOA’s Annual Meeting.

“Infected nonunion is a important challenge,” states Dr. Javad Parvizi, Orthopaedic Surgeon and Director of Scientific Exploration at the Rothman Institute. “Individuals undergo prolonged intervals of disability and loss of purpose, and even stand to drop a limb. It also imparts an enormous financial stress on the culture. Dr. Goswami and colleagues must be congratulated for investigating this essential situation. Their conclusions are sobering and lend help to the purpose of the microbiome contributing to these infections.”

Dr. Goswami’s paper, a future multicenter review, believed the microbial contribution to fracture nonunion making use of following-generation DNA sequencing (NGS) techniques which includes 16S rRNA gene profiling. Benefits indicated that NGS detection of pathogens was appreciably correlated with persistent nonunion (X2=6.1 p=.048). NGS was optimistic in 77% additional situations of non-union than regular tradition. Variances in microbial composition amongst individual consequence groups were also assessed. The analyze uncovered that elevated bacterial diversity was affiliated with compromised affected person outcomes (R2=.17 p<0.001).

“The fracture-associated microbiome detected using NGS appears to be a significant risk factor for persistent nonunion,” says Dr. Goswami. “20 microbial species were especially predictive of poorer outcome within our interim analysis.”

The research was funded by MicroGen Diagnostics and NGS testing was performed by MicroGen Diagnostics.

About Karan Goswami, MD

Dr. Goswami completed medical training at Oxford University and Imperial College, followed by further surgical training at the Royal College of Surgeons. As part of a Ph.D. thesis, Dr. Goswami focused on molecular diagnostics for musculoskeletal infection, and has published over 85 peer-reviewed academic papers and book chapters. He is currently an Orthopedic surgery resident at the Rothman Institute at Thomas Jefferson University. He has no conflict of interest.

About Javad Parvizi, MD, FRCS

Dr. Parvizi holds the James Edwards chair of orthopedics at Sidney Kimmel Medical School in Philadelphia. He is an active orthopedic surgeon with interest in management of orthopedic infections. He has published over 800 peer-reviewed articles, numerous text books and has been the recipient of grants from the NIH, DOD, OREF, and numerous other funding bodies for his work in orthopedic infections. He serves as scientific advisor to MicroGenDX and holds equity in the company.

About MicroGenDX

Founded in 2008, MicroGenDX has become the industry leader in rapid turnaround and affordability for comprehensive Next-Generation Sequencing (NGS) and qPCR testing for clinical diagnostics. MicroGenDX is CLIA-licensed and CAP-accredited, and has been the trusted research partner for the CDC, U.S. Army, NASA and the FDA. MicroGenDX has published over 35 clinical trials and is the most experienced molecular diagnostic laboratory with some 1.5 million samples processed. Over 80,000 medical professionals rely on MicroGenDX clinical diagnostics. 

Source: Eastern Orthopaedic Association

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